Given the expansion of eutrophication in water bodies around the world, the improved management of manure to mitigate P losses to water has become a global concern. This chapter seeks to frame manure management strategies and practices to minimize P losses to water, with a focus on manure properties, land application, farmstead infrastructure, farming systems. Although many options exist to better manage manure, and, more specifically, P in manure, doing so requires comprehensive approaches that consider factors far beyond the direct handling of manure and require decisions that may compete or conflict with other priorities, most notably profits and time management.