The EcoTrends project has generated hundreds of standardized, documented datasets from many sites and scientific fields.  During the process of generating data comparable between many sites and across several organizational networks, novel solutions to technical, organizational, and communication challenges have been created.  This chapter presents ten recommendations for site-level information management and for future synthesis projects.  The recommendations are related to three broad categories: (1) data management and products, (2) project design, and (3) information environments to support synthesis projects. For each recommendation, the chapter provides specific examples of the challenges that EcoTrends faced, the lessons learned, and then explains the recommendation that may help address the challenge in future projects.