In February 2014 the USDA established regional climate hubs across the United States to assist farmers, ranchers and foresters in adapting to the effects of climate change. The Southwest (SW) region encompasses six states which provide highly diverse agricultural crops including cotton, stone fruit and grapes. Here we report on the establishment of programs to assist SW working landowners with the impacts of climate change, with focus on the water resources of the region. Water is a critical component of agricultural vulnerability in the SW, where high agricultural production can occur with sufficient irrigation. Since 1978, crop yield declines were reported on 11-21% of total irrigated acres, mostly due to surface water shortage. Southwestern agriculture relies heavily on groundwater, using it to supply more than one-third of the agricultural water demand since 1955. Regional groundwater use varies over time, with a decline in the agricultural groundwater fraction in Arizona, but an increase in the fraction in Nevada and Utah. Observed and predicted changes in the southwestern hydrologic cycle can impact regional agriculture. Observed records show an increase in the fraction of precipitation falling as rain, which is expected to continue with future warming. Warming causes the snowmelt to peak earlier in the season and can reduce water available to crops during the summer months without additional water storage. Observed records indicate streamflow has shifted earlier in the year, most notably in snow dominated watersheds a continuation of this trend may challenge regional agriculture by further limiting water supply.